RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Smad2
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; etc.
Target
Tbr1; Smad2
Pathway
TGF-B signaling pathway
PubMed ID
Title
MiR-27b inhibits fibroblast activation via targeting TGFB signaling pathway
Year
2016
Function
MiR-27b was down-regulated in fibrotic lungs and fibroblasts from an experimental mouse model of pulmonary fibrosis. MiR-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFB receptor 1 and SMAD2.